Przejdź do treściGeneral Medical Discoveries · Large randomised clinical trial
In people with STEMI who also have disease in several coronary arteries, clinicians often need to decide which remaining narrowings should be treated. In the international AIR-STEMI trial, 1,823 patients were randomly assigned after successful treatment of the culprit lesion to complete revascularisation guided either by functional coronary angiography or by conventional angiography. After a median follow-up of 17.9 months, the composite outcome of death, another myocardial infarction, stroke or TIA, or ischaemia-driven repeat revascularisation occurred in 8.9% of the physiology-guided group and 13.7% of the angiography-guided group. The combined safety outcome of contrast-associated acute kidney injury or major bleeding was also less frequent with the functional strategy. An orthopaedic surgeon reading this large human randomised trial should note that it applies to a specific group of patients after STEMI and does not mean that a patient can decide independently whether a coronary narrowing needs a stent.
Source: Biscaglia S, Erriquez A, Colaiori I, et al. Complete Revascularization Guided by Functional Coronary Angiography in STEMI. New England Journal of Medicine. Published online 29 August 2026; 2026;395:972–982. DOI: 10.1056/NEJMoa2605373. PMID: 42670979. Source record rechecked 16 September 2026; this patient summary uses the publisher abstract and bibliographic data from NEJM and PubMed.
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Content prepared by: Tomasz Poboży - orthopaedic surgeon.